RESEARCH PROGRAMMES
We are interested in studying the biochemical and immunological cross-talk among dietary components, the gut microbial jungle and us. Our long-term goal is to identify mechanisms through which the cross-talk impact on our health and to develop a quantitative framework for evaluating disease risks. You can read on to find out more about these research programmes below.
WEIGHT LOSS SURGERY
We have investigated metabolic, microbial and immunological effects induced by weight loss surgery, in particular, Roux-en-Y gastric bypass. We found that the surgery profoundly disturbed host-microbial co-metabolism and resulted in a significant shift in the gut bacterial composition from Firmicutes to Proteobacteria.
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Key Publications:
Li et al. (2011) Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 60(9):1214
Seyfried et al. (2013) Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice. J Proteome Res. 12(3):1245
Collaborators:
Hutan Ashrafian - Imperial College London, UK
Florian Seyfried - University of Würzburg, Germany
Nana Gletsu-Miller - Purdue University, USA